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Ludwig Erik Aguilar

Chonbuk National University, South Korea

Title: On-demand release of paclitaxel and 5-flourouracil using thermoresponsive poly(NIPAAm-co-HMAAm)/polyurethane partnered with alternating magnetic field induced hyperthermia on non-vascular nitinol stent

Biography

Biography: Ludwig Erik Aguilar

Abstract

Gastrointestinal malignancies have been a tremendous problem in the medical field and cover a wide variety of parts of the system, (i.e., esophagus, duodenum, intestines and rectum). Usually these malignancies are treated with palliation with the use of nonvascular nitinol stents. However, stenting is not a perfect solution for the problem. While it can enhance the quality of life of the patient, in time the device will encounter problems such as reocclusion due to the rapid growth of the tumor. Therefore, a functional cover made up of core-shell nanofibers with a unique combination of thermo responsive polymeric shell and stretchable polymeric core for non-vascular nitinol stents that uses an alternating magnetic field (AMF) to induce heat in the stent for hyperthermia therapy and simultaneously release 5-fluorouracil and/or paclitaxel was designed. Varied ratios of NIPAAm to HMAAm monomer resulted in different LCST properties was utilized for an on-demand drug release. Biocompatibility test using NIH-3T3 fibroblast cells indicates that the composite with drug content are biocompatible and the in vitro cancer cytotoxicity test using ESO26 and OE21 cancer cells proved that the material shows cancer cytotoxic properties via combination of dual drug and hyperthermia therapy. With this functional material, we propose a tailorable and on-demand drug release with more control that can be employed for a combination drug therapy/single drug therapy combined with hyperthermia therapy for cancer cytotoxicity effect.

Recent Publications

  1. Aguilar LE, GhavamiNejad, A., Park, C.H.,Kim, C.S. On-Demand Drug Release and Hyperthermia Therapy Applications of Thermoresponsive poly- (NIPAAm-co-HMAAm)/Polyurethane Core-shell Nanofiber mat on Non- vascular Nitinol Stents. Nanomedice; Nanotechnology, Biology, and Medicine 2016;13:1-8.
  2. GhavamiNejad A, SamariKhalaj M, Aguilar LE, Park CH, Kim CS. pH/NIR Light-Controlled Multidrug Release via a Mussel-Inspired Nanocomposite Hydrogel for Chemo-Photothermal Cancer Therapy. Sci Rep-Uk 2016;6.
  3. Kim JI, Hwang TI, Aguilar LE, Park CH, Kim CS. A Controlled Design of Aligned and Random Nanofibers for 3D Bi-functionalized Nerve Conduits Fabricated via a Novel Electrospinning Set-up. Sci Rep-Uk 2016;6.
  4. GhavamiNejad A, Aguilar, L.E., Ambade, R.,Lee, S.H,Park,C.H,Kim, C.S. Immobilization of Silver Nanoparticles on Electropolymerized Polydopamine Films for Metal Implant Applications. COLLOIDS AND INTERFACE SCIENCE COMMUNICATIONS 2015;6:5-8.
  5. Aguilar LE, Unnithan AR, Amarjargal A, Tiwari AP, Hong ST, Park CH, et al. Electrospun polyurethane/Eudragit (R) L100-55 composite mats for the pH dependent release of paclitaxel on duodenal stent cover application. Int J Pharmaceut 2015;478:1-8.